Figure 6.

Normalized coronal (a, c) and axial (b, d) PET images of [¹⁸F]DPA-714 at day 7 after middle cerebral artery occlusion (MCAO) in vehicle (a, b) and JWH133 (c, d) rats. PET images are co-registered with a MRI (T₂W) rat template to localize anatomically the PET signal. [¹⁸F]DPA-714 uptake was quantified in vehicle (n = 5) and JWH133 (n = 7) at day 7 after ischemia as %ID/cc (mean ± SD) in the cerebral hemispheres, cortex and striatum (e–f). The neurologic score shows similar neurologic outcome at day 1 after ischemia (before the start of treatment) followed by a neurological outcome improvement at day 7 after cerebral ischemia (g). *p < 0.05 compared with vehicle; ^##p < 0.01 compared with day 1.