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AKSLHNs Enhance In Vivo Downregulation of K-ras G12S mRNA and Protein
(A) Western blot analysis shows an enhanced downregulation of target protein (K-ras mRNA) by AKSLHNs (nanoparticles) in comparison with PBS and combination treatment. Erlotinib-treated lung tumors also show some downregulation. (B) TaqMan qRT-PCR shows that AKSHLNs (nanoparticles) downregulated K-ras mRNA by approximately 50% in comparison with PBS. n = 3; **p ≤ 0.01; ***p ≤ 0.001. Error bars are ± SD.
