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. 2017 Feb 9;6:279–289. doi: 10.1016/j.omtn.2017.01.004

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© 2017.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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In Vivo NK0144-Mediated Inhibition of Ischemia-Induced Retinal NV in OIR Retinas

Each RNAi agent was intravitreally injected at P12 soon after returning to room air. (A) Representative images of the neovascular tufts and avascular areas at P17 in each treatment group. (B) The percentage of the neovascular tufts in NK0144 treatment group was significantly smaller than that of scramble RNAi agents. The inhibitory effect of NK0144 on preretinal pathological NV is significantly greater than that of NI0079. The avascular area of novel single-stranded RNAi agents (NK0000 and NK0144) treatment group was significantly smaller than canonical double-stranded siRNAs (NI0000 and NI0079) treatment group (n = 4/group). *p < 0.001, **p < 0.05. Error bars are SEM.