Table 1.
Syndromes of Genetic Predisposition Found among Children with Cancer and the Corresponding Affected Genes
| Genetic Predisposition | Affected Genea |
|---|---|
| Li-Fraumeni syndrome | TP53/CHK2/SNF5 |
| Familial Wilms tumor | FTW1/2 |
| Familial retinoblastoma | RB1 |
| Fanconi anemia | FANCA |
| IgA deficiency | IGAD1 |
| Blood syndrome | BLM |
| Wiskott-Aldrich syndrome | WAS |
| Ataxia telangiectasia | ATM |
| Familial adenomatous polyposis | APC |
| Hereditary non-polyposis colon cancer | MSH2/MLH1/PMS2 |
| Tuberous sclerosis | TSC1/2 |
| Beckwith-Wiedemann syndrome | Complex |
| Xeroderma pigmentosum | ERCC2 |
a
Children’s Health and the Environment, WHO Training Package for the Health Sector (World Health Organization, http://www.who.int/ceh).