Table 2. Univariable and Multivariable Analysis for RFS from Primary Cancer Diagnosis and OS from Diagnosis of Metastasis.

RFS FROM PRIMARY CANCER DIAGNOSIS
	All Patients			HR-Positive Patients
Covariate	Univariable	Multivariable		Univariable	Multivariable
	P Value	HR (95% CI)	P Value	P Value	HR(95%CI)	P Value
Age
≤ 50	0.059	1		0.231	1
> 50		1.28(0.98-1.66)	0.066		1.21 (0.90-1.65)	0.213
Subtype
HR-positive, HER2-negative		1
HER2-positive	<0.001	2.74 (1.59-4.72)	<0.001
TNBC		1.58 (1.11-2.25)	0.011
Grade
I-II	<0.001	1		<0.001	1
III		1.27 (0.97-1.65)	0.086		1.44 (1.07-1.94)	0.018
Stage at Diagnosis
0-I		1			1
II	<0.001	1.58 (1.12-2.23)	0.009	<0.001	1.73 (1.17-2.56)	0.006
III		1.99 (1.33-3.00)	0.001		1.47 (0.92-2.34)	0.110
Neoadjuvant Chemotherapy
No	<0.001	1		<0.001	1
Yes		1.22 (0.93-1.60)	0.146		1.66 (1.20-2.31)	0.003
Surgery Type
Breast-Conserving	0.005	1		0.030	1
Mastectomy		1.23 (0.91-1.66)	0.184		1.35 (0.94-1.94)	0.101
Mutation
AKT1-mutated		0.89 (0.51-1.53)	0.663		0.92 (0.51-1.64)	0.770
PIK3CA-mutated		0.85 (0.65-1.13)	0.266		0.83 (0.61-1.13)	0.241
TP53-mutated		1.48 (1.10-1.98)	0.009		1.64 (1.15-2.33)	0.006
OS FROM DIAGNOSIS OF METASTASIS
	All Patients			HR-Positive Patients
Covariate	Univariable	Multivariable		Univariable	Multivariable
	P Value	HR (95% CI)	P Value	P Value	HR(95%CI)	P Value
Subtype
HR-positive, HER2-negative	<0.001	1
HER2-positive		0.28 (0.13-0.63)	0.002
TNBC		2.37 (1.57-3.58)	<0.001
Grade
I-II	<0.001	1		< 0.001	1
III		1.38 (0.97-1.96)	0.072		1.50 (1.02-2.20)	0.037
First Metastatic Site
Bone	0.058	1		0.168	1
Visceral		1.21 (0.85-1.73)	0.298		1.57 (1.02-2.39)	0.038
Soft Tissue		0.63 (0.37-1.08)	0.090		0.52 (0.26-1.03)	0.064
Brain or Multiple		1.44 (0.87-2.37)	0.154		1.32 (0.69-2.53)	0.41
Mutation
AKT1-mutated		0.61 (0.24-1.52)	0.289		0.65 (0.26-1.65)	0.367
PIK3CA-mutated		0.84 (0.58-1.22)	0.370		0.88 (0.59-1.32)	0.540
TP53-mutated		1.44 (1.00-2.07)	0.048		2.20 (1.41-3.44)	0.001