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. 2016 Oct 24;7(47):76635–76646. doi: 10.18632/oncotarget.12850

Table 5. Biodistribution of the 99mTc-labeled NPs in male BALB/c nu/nu mice bearing SKOV-3 Xenografts, at 3 and 9 hours after intravenous injection.

Organ Uptake (% ID/g) Tumor-to-organ ratio
3 h 9 h 3 h 9 h
Liver 23.1 ± 1.84 6.50 ± 1.11 0.92 0.95
Kidney 22.73 ± 2.90 6.23 ± 0.96 0.93 0.99
Spleen 13.28 ± 0.81 2.45 ± 0.69* 1.6 2.51
Blood 13.18 ± 0.42* 2.20 ± 0.66* 1.61 2.79
Stomach 4.31 ± 0.20* 0.89 ± 0.39 4.93 6.9
Lung 0.88 ± 0.04* 0.16 ± 0.06* 24.16 38.38
Tumor 21.26 ± 1.27 6.14 ± 1.45
Bone 0.48 ± 0.14* 0.07 ± 0.03** 44.29 87.71
Thyroid 0.44 ± 0.02* 0.12 ± 0.04** 48.32 51.17
Heart 0.41 ± 0.12* 0.09 ± 0.02** 51.85 68.22
Intestines 0.40 ± 0.14* 0.11 ± 0.04* 53.15 55.82
Muscle 0.23 ± 0.07* 0.04 ± 0.01** 92.44 153.5
*

Significant difference of the % ID/g between tumor and other organs (p < 0.05).

**

Significant difference of the % ID/g between tumor and other organs (p < 0.01).

% ID/g = percent injected dose per gram of tissue.