Table 5. Biodistribution of the 99mTc-labeled NPs in male BALB/c nu/nu mice bearing SKOV-3 Xenografts, at 3 and 9 hours after intravenous injection.
Organ | Uptake (% ID/g) | Tumor-to-organ ratio | ||
---|---|---|---|---|
3 h | 9 h | 3 h | 9 h | |
Liver | 23.1 ± 1.84 | 6.50 ± 1.11 | 0.92 | 0.95 |
Kidney | 22.73 ± 2.90 | 6.23 ± 0.96 | 0.93 | 0.99 |
Spleen | 13.28 ± 0.81 | 2.45 ± 0.69* | 1.6 | 2.51 |
Blood | 13.18 ± 0.42* | 2.20 ± 0.66* | 1.61 | 2.79 |
Stomach | 4.31 ± 0.20* | 0.89 ± 0.39 | 4.93 | 6.9 |
Lung | 0.88 ± 0.04* | 0.16 ± 0.06* | 24.16 | 38.38 |
Tumor | 21.26 ± 1.27 | 6.14 ± 1.45 | − | − |
Bone | 0.48 ± 0.14* | 0.07 ± 0.03** | 44.29 | 87.71 |
Thyroid | 0.44 ± 0.02* | 0.12 ± 0.04** | 48.32 | 51.17 |
Heart | 0.41 ± 0.12* | 0.09 ± 0.02** | 51.85 | 68.22 |
Intestines | 0.40 ± 0.14* | 0.11 ± 0.04* | 53.15 | 55.82 |
Muscle | 0.23 ± 0.07* | 0.04 ± 0.01** | 92.44 | 153.5 |
Significant difference of the % ID/g between tumor and other organs (p < 0.05).
Significant difference of the % ID/g between tumor and other organs (p < 0.01).
% ID/g = percent injected dose per gram of tissue.