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. 2016 Oct 8;7(47):76756–76768. doi: 10.18632/oncotarget.12525

Figure 2. ESE3/EHF transcriptionally represses IL-6.

Figure 2

(A) Predicted ETS binding sites (EBS) in the human IL-6 promoter (left). Position relative to the transcription start site (TSS) of the gene, sequence, corresponding scores (right) and EHF scanned motif logo (lower left). (B) Binding of ESE3/EHF to the IL-6 promoter (left panel) and chromatin marks (right panel) determined by chromatin immunoprecipitation (ChIP) in LNCaP cells. (C) Transcriptional activity of IL-6 promoter reporters in control (pcDNA) and stably ESE3/EHF expressing (pESE3) DU145 cells evaluated by dual luciferase assay. P values were determined using t-test. *P < 0.05; **P < 0.01. Data are representative of three independent experiments.