Figure 7. IL-6 elevation and loss of ESE3/EHF are associated with STAT3 activation and inflammatory features in human prostate tumors.

(A) Box–plots showing the level of IL-6 (left) and ESE3/EHF (right) in the selected tumor populations. (B) Transcription factor analysis of the top genes activated in IL-6_high/ESE3_low compared to all the other tumors using CHEA by Enrich. (C) Number of ESE3/EHF putative binding sites among the top activated genes in the IL-6_high/ESE3_low signature. (D) Functional annotation analysis by Metacore using the upregulated genes. (E) GSEA using indicated list of genes and comparing IL-6_high/ESE3_low with all the other tumors in the EHRO dataset.