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. 2016 Oct 20;7(47):77038–77051. doi: 10.18632/oncotarget.12781

Figure 3. Effects of GSK-3β inhibitors on the proliferation and apoptosis of osteosarcoma cells and osteoblasts.

Figure 3

(A) The indicated cells were treated with DMSO or 25 μmol/L each of either AR-A014418 or SB-216763 for 72 hours. The relative number of proliferating cells was evaluated by measuring the amount of BrdU incorporation. (B) Relative numbers of TUNEL-positive apoptotic cells were scored for the indicated cells at 12 hours after treatment with DMSO or 25 μmol/L each of either GSK-3β inhibitor. (A, B) Values shown are the means ± SD of six separate experiments. Asterisks denote a statistically-significant difference (p < 0.01) between cells treated with DMSO and either GSK-3β inhibitor.