Table 1. Meta-analysis using public datasets showing correlation between ERRα and VEGFA, WNT5A, POSTN and TGFb1 expression levels in bone metastases (GSE29650, GSE41619 and GSE74685) and/or in primary CRPC tumor (GSE1034, GSE6919 and GSE2269).

			Number of samples (N)
Genes names	Database	Correlations	Primary tumour	Bone Metastases
VEGFA/ERRA	GSE21034/ GSE6919/ GSE32269	Pearson R = 0.364 P = 0.00001	140 CRPC	N/A
	GSE29650/ GSE41619/GSE74685	Pearson R = 0.646 P = 0.000001	N/A	64
WNT5A/ERRA	GSE21034/ GSE6919/ GSE32269	Pearson R =−0.178 P = 0.035	140 CRPC	N/A
	GSE29650/ GSE41619/GSE74685	Pearson R = 0.342 P = 0.00572	N/A	64
POSTN/ERRA	GSE21034/ GSE6919/ GSE32269	Pearson R = 0.401 P = 0.000001	184 in adjacent normal tissue	N/A
	GSE29650/ GSE41619	Pearson R = 0.528 P = 0.00023	N/A	44
TGFb1/ERRA	GSE21034/ GSE6919/ GSE32269	Pearson R = 0.684 P = 0.000001	140 CRPC	N/A
	GSE29650/ GSE41619	Pearson R =−0.365 NS	N/A	14

To obtain z-scores, normalized data were log₂ transformed and calculated by subtracting the population mean from individual expression values for each gene and then dividing the difference by the population standard deviation. Correlation scores were calculated using the Pearson correlation coefficient. P-values less than 0.05 were considered statistically significant.