Table 1. Pharmacokinetic (PK) parameters of docetaxel (DTX) from plasma data on day 1 of PNP-DTX injection.
| PK parameter | Dose of PNP-DTX (mg/m2/d) | ||||||
|---|---|---|---|---|---|---|---|
| Dose | 20 | 35 | 45 | 60 | 75 | ||
| Group | 1 | 2 | 3 | 4 | 5 | ||
| No. of enrolled patients | 6 | 3 | 3 | 6 | 1 | ||
| Cmax (mg/L) | Mean | 0.91 | 2.24 | 2.11 | 2.70 | 3.60 | |
| SD* | 0.20 | 0.57 | 0.43 | 0.54 | |||
| AUClast (hr·μg/L) | Mean | 1.44 | 3.87 | 2.95 | 4.51 | 5.57 | |
| SD* | 0.39 | 1.24 | 0.34 | 1.15 | |||
| AUCinf (hr·μg/L) | Mean | 1.59 | 4.09 | 3.14 | 4.82 | 5.77 | |
| SD* | 0.51 | 1.24 | 0.33 | 1.21 | |||
| Vd (L) | Mean | 727.56 | 391.08 | 667.12 | 688.00 | 547.66 | |
| SD* | 449.84 | 257.18 | 156.86 | 438.23 | |||
| CL (L/hr) | Mean | 23.31 | 14.56 | 23.71 | 22.32 | 24.62 | |
| SD* | 4.71 | 5.60 | 3.94 | 5.55 | |||
| t1/2β (hr) | Mean | 20.81 | 17.70 | 19.39 | 20.43 | 15.42 | |
| SD* | 9.64 | 6.51 | 1.68 | 7.47 | |||
*
SD: Standard deviation