Table 1. Selected variants at the FGFR2 locus and ER status among breast cancer cases.
| Overall | HER2+ | HER2− | |||||
|---|---|---|---|---|---|---|---|
| SNP | I/G* (Rsq, Quality) | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p |
| rs3135718 | I (0.64, 0.89) | 1.33 (1.23 - 1.45 | 6.0×10-12 | 1.19 (1.04 - 1.35) | 7.9×10-3 | 1.47 (1.30 - 1.64) | 2.0×10-10 |
| rs3135724 | I (0.41, 0.84) | 1.51 (1.33 - 1.69) | 8.1×10-11 | 1.18 (0.97 - 1.41) | 9.3×10-2 | 1.79 (1.49 - 2.13) | 5.2×10-11 |
| rs2981578 | G (NA, NA) | 1.24 (1.16-1.32) | 3.5×10-10 | 1.20 (1.09-1.33) | 3.3×10-4 | 1.26 (1.14-1.38) | 1.7×10-6 |
| rs2981579 | G (NA, NA) | 1.25 (1.16 - 1.33) | 5.5×10-11 | 1.15 (1.03 - 1.27) | 9.2×10-3 | 1.33 (1.20 - 1.47) | 2.1×10-9 |
*
Imputed (I) or genotyped (G). Values reported from MACH output