Table 1. Clinicopathological factors of NSCLC patients and expressions of miR-7 and its downstream proteins.

Clinicopathological factors	N	MiR-7	FAK mRNA	ERK mRNA	MAPK mRNA	FAK protein expression	ERK protein expression	MAPK protein expression
Gender
Male	107	1.206 ± 0.39	1.370 ± 0.314	0.939 ± 0.277	0.696 ± 0.294	1.276 ± 0.231	0.637 ± 0.233	0.628 ± 0.166
Female	53	1.220 ± 0.394	1.423 ± 0.332	0.939 ± 0.273	0.738 ± 0.265	1.255 ± 0.254	0.665 ± 0.149	0.651 ± 0.154
P		0.833	0.325	1.000	0.396	0.612	0.413	0.397
Age (years)
< 50	45	1.189 ± 0.398	1.350 ± 0.340	0.937 ± 0.295	0.747 ± 0.301	1.282 ± 0.221	0.659 ± 0.197	0.641 ± 0.169
≥ 50	115	1.219 ± 0.389	1.402 ± 0.313	0.940 ± 0.268	0.697 ± 0.278	1.264 ± 0.245	0.641 ± 0.213	0.633 ± 0.160
P		0.671	0.361	0.936	0.333	0.674	0.629	0.801
LNM
Positive	93	1.035 ± 0.206	1.579 ± 0.229	1.121 ± 0.162	0.886 ± 0.238	1.427 ± 0.160	0.755 ± 0.150	0.721 ± 0.157
Negative	67	1.456 ± 0.450	1.122 ± 0.224	0.688 ± 0.186	0.467 ± 0.112	1.049 ± 0.130	0.496 ± 0.185	0.516 ± 0.064
P		< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001
TNM stage
I/II	81	1.361 ± 0.470	1.203 ± 0.282	0.773 ± 0.256	0.535 ± 0.208	1.106 ± 0.177	0.544 ± 0.204	0.544 ± 0.106
III/IV	79	1.057 ± 0.191	1.578 ± 0.235	1.110 ± 0.167	0.890 ± 0.237	1.436 ± 0.167	0.751 ± 0.155	0.729 ± 0.157
P		< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Tumor location
Left	61	1.248 ± 0.375	1.363 ± 0.308	0.942 ± 0.292	0.729 ± 0.314	1.276 ± 0.243	0.670 ± 0.178	0.657 ± 0.159
Right	99	1.188 ± 0.400	1.403 ± 0.327	0.938 ± 0.265	0.699 ± 0.266	1.264 ± 0.237	0.632 ± 0.225	0.622 ± 0.163
P		0.347	0.444	0.920	0.490	0.763	0.267	0.185
Tumor size
< 5 cm	93	1.176 ± 0.357	1.326 ± 0.275	0.884 ± 0.275	0.659 ± 0.320	1.199 ± 0.258	0.599 ± 0.214	0.596 ± 0.147
≥ 5 cm	67	1.259 ± 0.43	1.426 ± 0.34	0.973 ± 0.27	0.742 ± 0.257	1.312 ± 0.216	0.675 ± 0.201	0.659 ± 0.167
P		0.189	0.520	0.943	0.993	0.799	0.778	0.619
Histological type
Squamous cell carcinoma	80	1.209 ± 0.400	1.407 ± 0.302	0.952 ± 0.255	0.711 ± 0.290	1.261 ± 0.242	0.653 ± 0.223	0.628 ± 0.168
Adenocarcinoma	62	1.201 ± 0.368	1.376 ± 0.331	0.932 ± 0.287	0.710 ± 0.283	1.274 ± 0.237	0.642 ± 0.200	0.640 ± 0.159*
others	18	1.254 ± 0.438	1.381 ± 0.321	0.944 ± 0.299	0.672 ± 0.265	1.236 ± 0.222	0.632 ± 0.174	0.664 ± 0.191
P		0.879	0.264	0.587	0.574	0.819	0.387	0.662

NSCLC, non-small-cell lung carcinoma; miR-7, microRNA-7; FAK, focal adhesion kinase; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; LNM, lymph node metastasis; TNM, tumor node metastasis;