Figure 8. CD44 knockdown markedly reduced the level of ERK1/2 phosphorylation, Smad2 phosphorylation and YAP expression.

A, B., and increased YAP phosphorylation C. By an online database (http://string-db.org/), eight proteins including PPP1R16A, PPP1R16B, SLC32A1, CSNK1E, CSNK1A1, UBC, KIF4A, KIF22 were considered as potential protein interacting with FAM83D D. The map of molecular mechanism underlying FAM83D drives expansion of CD44 positive CSCs E.