Table 1. Prognostic value of proportion of tumour by treatment arm.
| PoT grouping | Pre-op chemotherapy followed by surgery | Surgery alone | ||||
|---|---|---|---|---|---|---|
| N | Median OS | HR (95% CI) | N | Median OS | HR (95% CI) | |
| Continuous | 140 | 1.00 (0.99, 1.01) | 141 | 0.99 (0.98, 1.00) | ||
| Binary | ||||||
| <50% | 51 | 1.25 | 1 | 49 | 1.45 | 1 |
| ≥50% | 89 | 1.85 | 0.83 (0.56, 1.23) | 92 | 1.10 | 0.93 (0.65, 1.34) |
| Tertiles | ||||||
| ≤49.15 | 47 | 1.11 | 1 | 47 | 1.45 | 1 |
| 49.16 – 64.03 | 49 | 1.92 | 0.71 (0.45, 1.13) | 46 | 1.05 | 1.10 (0.72, 1.68) |
| >64.03 | 44 | 1.46 | 0.92 (0.59, 1.46) | 48 | 1.11 | 0.84 (0.54, 1.30) |
| Final grouping | ||||||
| <40 | 29 | 0.95 | 1* | 17 | 1.21 | 1† |
| 40-70 | 84 | 1.98 | 0.59 (0.37, 0.97)* | 99 | 1.10 | 0.75 (0.44, 1.27)† |
| ≥70 | 27 | 1.20 | 1.20 (0.69, 2.11)* | 25 | 1.78 | 0.50 (0.26, 0.97)† |
Values of significance are highlighted and typed in bold. Abbreviations: CI: confidence interval: HR: hazard ratio; OS: overall survival (years); PoT: proportion of tumour.
*
test for interaction of heterogeneity of treatment effect across groups, P=0.006
†
log-rank trend P-value=0.0359