Table 4. The relationship between clinicopathological characteristics, ph-STAT1 and ph-STAT3 tumour cell expression and cancer specific survival in patients with invasive ductal breast cancer (n=384).

	Univariate analysis		Multivariate analysis
	HR (95% CI)	P-value	HR (95% CI)	P-value
Age (≤50/ >50 years)	1.14(0.70-1.85)	0.604
Size (≤20/ 21-50/ >50 mm)	2.21(1.52-3.23)	<0.001		0.475
Grade (I / II / III)	1.89(1.37-2.63)	<0.001		0.254
Involved lymph node (−ve/+ve)	3.85(2.37-6.24)	<0.001	1.90(1.10-3.29)	0.021
ER status (no/yes)	0.54(0.35-0.84)	0.006		0.141
PR status (no/yes)	0.58(0.38-0.90)	0.015		0.181
Her-2 status (no/ yes)	2.05(1.26-3.32)	0.004		0.272
Tumour necrosis (low/high)	5.87(3.26-10.67)	<0.001	4.42(2.31-8.45)	<0.001
Lymphatic vessel invasion (no/yes)	4.08(2.61-6.37)	<0.001	1.94(1.13-3.31)	0.015
Blood vessel invasion (no/yes)	3.28(1.98-5.43)	<0.001	1.79(1.02-3.14)	0.044
Klintrup–Mäkinen grade (low/high)	1.47(0.93-2.23)	0.099		0.526
CD68+ (low/moderate/high)	0.79(0.59-1.02)	0.069		0.101
CD4+ (low/moderate/high)	0.99(0.78-1.26)	0.982
CD8+ (low/moderate/high)	0.62(0.47-0.82)	<0.001	0.58(0.42-0.80)	0.003
CD138+(low/moderate/high)	1.34(1.06-1.69)	0.014	1.65(1.25-2.18)	<0.001
Tumour stroma percentage (low/high)	2.17(1.40-3.35)	<0.001		0.096
Tumour budding (low/high)	2.46(1.59-3.78)	<0.001	1.88(1.17-3.03)	0.009
Ph-STAT1 tumour cell expression (low/moderate/high)	0.65(0.49-0.86)	0.002		0.193
Ph–STAT3 tumour cell expression (low/moderate/high)	0.54(0.40-0.74)	<0.001	0.64(0.64-0.90)	0.010
Locoregional treatment (lumpectomy +radiotherapy/mastectomy+radiotherapy)	2.62(1.55-4.42)	0.001		0.054
systemic treatment (hormonal/hormonal +chemotherapy/chemotherapy/none)	1.26(1.02-1.55)	0.020		0.408