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. 2016 Oct 20;7(47):77696–77706. doi: 10.18632/oncotarget.12773

Figure 6. Lipotoxicity in neuroblastoma.

Figure 6

A. Effect of enhanced delivery of FA was tested in neuroblastoma cell lines treated with increasing amounts of albumin loaded with palmitate in normoxic and hypoxic conditions. While in normoxic conditions treatment with FA caused toxicity in some cell lines, in hypoxic conditions lipotoxicity was observed in all nine cell lines. For direct comparison, the data are shown as relative to the treatment with BSA control at 0 uM point. B. SPARC regulates lipid physiology and metabolism by enhancing delivery of FA to the target tissues. Without SPARC, lower amounts of FA-carrying albumin is transported to subluminal compartments. In the presence of SPARC, rate of albumin transcytosis is significantly higher, and larger amounts of FA are delivered to the target tissues.