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. 2016 Oct 20;7(47):77707–77720. doi: 10.18632/oncotarget.12774

Figure 6. Reduction of SIRT1 enhances adipogenic potential in vivo.

Figure 6

A. Comparison of SIRT1+/+ and SIRT1+/−before and after killing in aged 12w mice. B. Body weight of SIRT1+/+ and SIRT1+/− in aged 12w mice. Bars indicate SD, n=7. C. Fat mass weight relative to total body weight composition of SIRT1+/+ and SIRT1+/− in aged 12w mice. Bars indicate SD, n=7. D. BAT weight, BAT weight relative to total body weight composition of SIRT1+/+ and SIRT1+/− in aged 12w mice. Bars indicate SD, n=7. E. Liver weight, liver weight relative to total body weight composition of SIRT1+/+ and SIRT1+/− in aged 12w mice. Bars indicate SD, n=7. F. Blood triglyceride level in SIRT1+/+and SIRT1+/− in aged 12w mice. Bars indicate SD, n=7. G. BAT and WAT of epididymal fat pad. H. Hematoxylin and eosin staining of BAT, subcutaneous adipose tissue (inguinal) and visceral adipose tissue (epididymal) of SIRT1+/+ and SIRT1+/− in aged 12w mice. I. The mRNA expression of adipocyte markers (PPARγ, aP2 and adiponectin) were determined in inguinal and epididymal of SIRT1+/+and SIRT1+/− mice by Real-time PCR. Bars indicate SD. *P < 0.05. n = 7. J. The mRNA expression of sFRP1, sFRP2, Dact1 and Cyclin D1 were determined in subcutaneous of SIRT1+/+ and SIRT1+/− mice by Real-time PCR. Bars indicate SD. n = 7.