Table 2. Clinicopathologic features and plasma level of PGC-1α.

Category	No. of cases	plasma level of PGC-1α Mean± SD	Statistics value	P value
Age
≤55	131	248.882±79.446	t= −4.464	0.643
>55	136	244.211±84.863
Tumor size
≤2cm	164	227.298±84.600	t'= −5.293	0.001
>2cm	103	277.080±67.940
Skin involvementa
No	227	242.790±83.707	t = −1.767	0.078
Yes	40	267.572±69.757
LN metastasisb
No	169	235.066±85.258	F=4.231	0.006
1~3	49	261.348±73.066
4~9	27	281.432±66.871
10~	13	283.345±78.256
Unknown	9
Histologic grade
≤II	206	242.499±80.471	t= −2.665	0.008
>II	50	276.416±81.712
Unknown	11
Hormone receptor
(−)	66	248.723±93.207	t'=0.289	0.773
(+)	188	245.019±78.746
Unknown	13
HER-2
(−~+)	116	237.449±72.534	t' = −0.956	0.340
(++~+++)	113	247.840±90.750
Unknown	38
Tumor typec
DCISd	26	202.973±81.314	F =3.191	0.024
IDCe	224	252.592±82.047
ILCf	5	215.200±64.216
OTHERg	12	240.260±66.221
Clinical stageh
I	115	216.291±83.529	F =15.275	0.001
II	83	266.301±75.351
III	69	273.040±71.450
HIF-1α plasma leveli
low	134	240.572±84.054	t = −1.185	0.237
high	133	252.477±80.014

^askin involvement includes: edema, redness, nodularity or ulceration of the skin

^bPost Hoc Multiple Comparisons(LSD) shows difference of PGC-1αconcentration only presence in the group without LN metastasis and the other groups

^cPost Hoc Multiple Comparisons(LSD) shows difference of PGC-1αconcentration only presence in the DCIS group and the other groups

^dDCIS: ductal carcinoma in situ

^eIDC: invasive ductal carcinoma

^fILC: invasive lobular carcinoma

^gOTHER include: mucinous or colloid carcinoma, medullary carcinoma, metaplastic carcinoma.

^hPost Hoc Multiple Comparisons(LSD) shows difference of PGC-1αconcentration only presence in the stage I group and the other groups

ⁱmedian of HIF-1α plasma level was 10.48 ng/dl