Table 3. Multivariate Analyses of DFS (Backward Stepwise, Likelihood Ratio).

Variable	HR	95%CI	P valuea
Tumor size
(≤2cm vs >2cm)	1.089	0.645 to 1.840	0.749
LN metastasis
(No vs Yes)	1.990	1.204 to 3.289	0.007
Histologic grade
(≤II vs >II)	1.470	0.797 to 2.711	0.217
Hormone receptor
(negative vs positive)	0.594	0.349 to 1.011	0.055
HER-2
(−~+ vs ++~+++)	1.015	0.610 to 1.687	0.955
HIF-1α plasma level
(low vs high)	1.429	0.861 to 2.373	0.167
PGC-1α plasma level
(low vs high)	1.582	0.951 to 2.633	0.077

^aP values less than 0.1 were considered as statistically significant in multivariate analyses