Table 2. Genotype and allele frequencies of FEN1 polymorphisms among the cases and controls and the associations with BC risk.

Model	Genotype	Case(560)	Control(583)	OR (95% CI)†	P-value*
rs4246215
Codominant	G/G	260 (46.4%)	245 (42.0%)	1.00 (reference)	0.026
	G/T	249 (44.5%)	256 (43.9%)	0.92 (0.72-1.17)	0.49
	T/T	51 (9.1%)	82 (14.1%)	0.59 (0.40-0.87)	0.007
Dominant	GG	260 (46.4%)	265 (43.9%)	1.00 (reference)
	G/T-T/T	300 (53.6%)	338 (56.1%)	0.84 (0.66-1.06)	0.13
Recessive	G/G-C/T	509 (90.9%)	501 (85.9%)	1.00 (reference)
	T/T	51 (9.1%)	82 (14.1%)	0.61 (0.42-0.89)	0.009
Overdominant	G/G-C/T	311 (55.5%)	327 (56.1%)	1.00 (reference)
	G/T	249 (44.5%)	256 (43.9%)	1.02 (0.81-1.29)	0.85
Allele	G	769 (68.7%)	746 (64.0%)	1.00 (reference)
	T	351 (31.3%)	420 (36.0%)	0.81 (0.68-0.96)	0.018
rs174538
Codominant	G/G	243 (43.4%)	233 (40.0%)	1.00 (reference)	0.32
	G/A	256 (45.7%)	272 (46.6%)	0.90 (0.70-1.16)	0.42
	A/A	61 (10.9%)	78 (13.4%)	0.75 (0.51-1.10)	0.14
Dominant	G/G	243 (43.4%)	233 (40.0%)	1.00 (reference)
	G/A-A/A	317 (56.6%)	350 (60.0%)	0.87 (0.69-1.10)	0.24
Recessive	G/G-G/AG	499 (89.1%)	505 (86.6%)	1.00 (reference)
	A/A	61 (10.9%)	78 (13.4%)	0.79 (0.55-1.13)	0.20
Overdominant	G/G-G/AG	294 (53.5%)	311 (53.3%)	1.00 (reference)
	A/A	256 (46.5%)	272 (46.7%)	0.96 (0.76-1.22)	0.75
Allele	C	742 (66.3%)	738 (63.3%)	1.00 (reference)
	T	378 (33.7%)	428 (36.7%)	0.88 (0.74-1.04)	0.14

^*Two-sided χ² test for the distributions of genotype and allele frequencies.

^†Adjusted for age and body mass index.