Table 2. Genotype and allele frequencies of FEN1 polymorphisms among the cases and controls and the associations with BC risk.
Model | Genotype | Case(560) | Control(583) | OR (95% CI)† | P-value* |
---|---|---|---|---|---|
rs4246215 | |||||
Codominant | G/G | 260 (46.4%) | 245 (42.0%) | 1.00 (reference) | 0.026 |
G/T | 249 (44.5%) | 256 (43.9%) | 0.92 (0.72-1.17) | 0.49 | |
T/T | 51 (9.1%) | 82 (14.1%) | 0.59 (0.40-0.87) | 0.007 | |
Dominant | GG | 260 (46.4%) | 265 (43.9%) | 1.00 (reference) | |
G/T-T/T | 300 (53.6%) | 338 (56.1%) | 0.84 (0.66-1.06) | 0.13 | |
Recessive | G/G-C/T | 509 (90.9%) | 501 (85.9%) | 1.00 (reference) | |
T/T | 51 (9.1%) | 82 (14.1%) | 0.61 (0.42-0.89) | 0.009 | |
Overdominant | G/G-C/T | 311 (55.5%) | 327 (56.1%) | 1.00 (reference) | |
G/T | 249 (44.5%) | 256 (43.9%) | 1.02 (0.81-1.29) | 0.85 | |
Allele | G | 769 (68.7%) | 746 (64.0%) | 1.00 (reference) | |
T | 351 (31.3%) | 420 (36.0%) | 0.81 (0.68-0.96) | 0.018 | |
rs174538 | |||||
Codominant | G/G | 243 (43.4%) | 233 (40.0%) | 1.00 (reference) | 0.32 |
G/A | 256 (45.7%) | 272 (46.6%) | 0.90 (0.70-1.16) | 0.42 | |
A/A | 61 (10.9%) | 78 (13.4%) | 0.75 (0.51-1.10) | 0.14 | |
Dominant | G/G | 243 (43.4%) | 233 (40.0%) | 1.00 (reference) | |
G/A-A/A | 317 (56.6%) | 350 (60.0%) | 0.87 (0.69-1.10) | 0.24 | |
Recessive | G/G-G/AG | 499 (89.1%) | 505 (86.6%) | 1.00 (reference) | |
A/A | 61 (10.9%) | 78 (13.4%) | 0.79 (0.55-1.13) | 0.20 | |
Overdominant | G/G-G/AG | 294 (53.5%) | 311 (53.3%) | 1.00 (reference) | |
A/A | 256 (46.5%) | 272 (46.7%) | 0.96 (0.76-1.22) | 0.75 | |
Allele | C | 742 (66.3%) | 738 (63.3%) | 1.00 (reference) | |
T | 378 (33.7%) | 428 (36.7%) | 0.88 (0.74-1.04) | 0.14 |
Two-sided χ2 test for the distributions of genotype and allele frequencies.
Adjusted for age and body mass index.