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Cumulative release studies show AD-DOX release is dependent on pH change. Due to the added affinity from the AD group, release from pCD polymers was shown to be very slow, with virtually no burst. Whereas at low, tumor pH the adamantane group is cleaved and the DOX is released at a much faster rate. The release observed is comparable to that seen by systems using chemically similar non-affinity pDextran polymers in either pH
