Fig. 5.

PHH spheroids constitute the most sensitive in vitro cell culture system tested. Heat map summarizing the sensitivities of the three cell systems to cytotoxicity, as shown in Fig. 4. Data are presented as mean centered and σ normalized and are related to therapeutic (ximelagatran and troglitazone) or toxic (APAP, aflatoxin B1, amiodarone, chlorpromazine) exposure values. Single, double, and triple asterisks indicate sensitivity < 30× C_max, < 10× C_max, and < 1× C_max, respectively. C_max or exposure values were obtained from the following references: APAP, 700 µM (Vale and Proudfoot, 1995); aflatoxin B1, 0.03 µM (Hassan et al., 2006); amiodarone, 3.9 µM (Regenthal et al., 1999); chlorpromazine, 1.6 µM, (Regenthal et al., 1999); troglitazone, 2.82 µM (Loi et al., 1999); and ximelagatran, 0.3 µM, (Schützer et al., 2004).