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. 2016 Dec 10;4:18–30. doi: 10.1016/j.omto.2016.11.003

Figure 2.

Figure 2

The Impact of Oncolysis on Morphology and Cell Cycle

(A) Following exposure to viruses, the morphology of A549 cells was evaluated by transmission electron microscopy (TEM), comparing cell morphologies at similar stage in the virus life cycle (scale bars show 1 μm in the main images and 100 nm for insets). (B) Cell-cycle analysis by flow cytometry, with cells treated as shown. Treatment conditions applied were as follows: EnAd, 10 ppc (POI day 3); Ad11, 25 ppc (POI day 3), and Ad5, 100 ppc (POI day 3.5); cisplatin (50 μM) assessed after 24 hr, H2O2 (1 mM) assessed after 4 hr.