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Tight and adherens junctions components. Tight junctions (TJs) are the most apical intercellular junctions in ECs. Their major transmembrane components are the claudins, occludin and adhesion molecules (JAMs), whereas their cytoplasmic components are zonula occludens (ZOs) proteins. Adherens junctions (AJs) are localized just below TJs; their transmembrane components are cadherins and nectins that complex respectively the cytoplasmic components β-catenin and afadin.
