Figure 3.
HSV and IRF3 IHC Staining in the CNS of CBA Mice Injected with 1 × 107 PFU C101 or C134
Low-magnification and corresponding high-magnification views of the CNS 6 days post-injection show limited HSV antigen detection in both the C101- and C134-inoculated mice. IRF3 staining is readily apparent in the C134-administered mouse CNS parenchyma and ependyma on D6 and coincides with the area of prior HSV detection in the mouse CNS. Composite representative images of the IHC-stained HSV-infected brains at D2, D4, D6, and D8 are provided in Figures S1 and S2 (low and high magnification, respectively).