TABLE 1.
Measures of potency and reinforcing effectiveness of MDPV, cocaine, and methamphetamine
Asterisk and pound signs indicate statistical significance: *P < 0.05 compared with all other drugs, #P < 0.05 compared with low responders. Group sizes: n = 7, high responders; n = 9, low responders; and n = 16, grouped.
| Parameter | Responder | MDPV | Cocaine | Methamphetamine |
|---|---|---|---|---|
| ED50 (±95% CI) | High | 0.016* (0.01, 0.02) | 0.15* (0.08, 0.23) | 0.036* (0.03, 0.04) |
| Low | 0.019* (0.01, 0.02) | 0.17* (0.14, 0.20) | 0.036* (0.03, 0.04) | |
| Grouped | 0.017* (0.01, 0.02) | 0.16* (0.11, 0.21) | 0.036* (0.03, 0.04) | |
| Emax (±S.E.M.) | High | 31.2# ± 0.7 | 25.0# ± 0.9 | 25.4# ± 0.9 |
| Low | 26.3 ± 1.3 | 20.7 ± 1.4 | 21.2 ± 1.2 | |
| Grouped | 28.1* ± 1.0 | 22.3 ± 1.1 | 22.8 ± 1.0 |
CI, confidence interval.