Table 2.
The results of relative risks for risk factors as initiators and promoters when considered jointly in the continuous-time exponential regression Markov model.
| Parameters | Model 1 |
Model 2 |
|---|---|---|
| aRR (95% CI) | aRR (95% CI) | |
| Initiators | ||
| BMI, ≥25 vs. <25 kg/m2 | 1.15 (0.99, 1.33) | 1.15 (0.99, 1.34) |
| Age at first full-term pregnancy, >25 y vs. ≤25 y | 1.23 (1.10, 1.38) | 1.23 (1.10, 1.38) |
| Breast density, Dense vs. Non-dense | 1.41 (1.19, 1.69) | 1.41 (1.19, 1.68) |
| Family history, Yes vs. No | 1.89 (1.36, 2.63) | 1.89 (1.36, 2.63) |
| Promoters | ||
| BMI, ≥25 vs. <25 kg/m2 | 0.65 (0.51, 0.82) | 0.65 (0.52, 0.81) |
| Breast density, Dense vs. Non-dense | 1.46 (1.12, 1.91) | 1.46 (1.13, 1.89) |
| Triple-negative, Yes vs. No | 2.07 (1.37, 3.15) | NA |
| Ki-67 expression, Pos. vs. Neg. | 1.66 (1.19, 2.30) | NA |
| Basal-like phenotype, Yes vs. No | 1.71 (0.95, 3.10) | NA |
| Molecular subtype | ||
| Luminal A | NA | 1.00 |
| Luminal B | NA | 1.74 (0.99, 3.04) |
| HER-2+ | NA | 1.51 (0.70, 3.26) |
| Basal-like subtype | NA | 4.24 (2.56, 7.02) |
| Triple-negative | NA | 2.06 (0.75, 5.69) |
aRR, adjusted relative risk; BMI, body mass index; CI, confidence interval; NA, not applicable.
Model 1: The effects of biomarkers were treated as independent.
Model 2: The combination of the status of ER, PR, HER-2 and basal-like phenotype was used to classify the cancer into 5 subtypes.