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. 2017 Jan 3;11(4):972–987. doi: 10.1038/ismej.2016.169

Figure 5.

Figure 5

P. putida KT2440 T6SS nucleases. (a, b) Multiple sequence alignments of the C-terminal domains of Tke2 (a) and Tke4 (b) effectors (blue) with known proteins of the family (black). Conservation logos of the motifs HNH (a) and SHH (b) are indicated above the alignment. Conserved residues are indicated with the color code used in Figure 4. A representation of the structural model of the C-terminal domain of the Tke2 effector (magenta) superimposed on the colicin E7 structure (blue; PDB: 2JB0) is shown on the right of a. Side chains of the active site residues are shown. (c) Multiple sequence alignment of T6SS colicin effectors (blue) with known proteins of the family (black). The secondary structure prediction (ssp) for effector Tke7 is shown above the alignment. A structural alignment of the Tke7 effector model (magenta) with the colicin S4 (blue, PDB: 3FEW) is shown on the right.