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. 2017 Mar 23;12(3):e0173984. doi: 10.1371/journal.pone.0173984

Fig 6. The protein contents of (A) GLUT4 in skeletal muscle, and phospho-Akt (Ser473)/total Akt, phospho-AMPK (Thr172) /total AMPK in both skeletal muscle and liver tissue of the mice by oral gavage (−)-epicatechin-3-O-β-D-allopyranoside (BB).

Fig 6

(A, B) representative image; (C, D) quantification of the GLUT4 expression levels and the ratio of phospho-Akt to total Akt and phospho-AMPK to total AMPK (mean ± SE, n = 9). Protein was separated by 12% SDS-PAGE detected by Western blot. # P < 0.05, ## P < 0.01, and ### P < 0.001 compared with the control (CON) group; * P < 0.05, ** P < 0.01, and *** P < 0.001 compared with the streptozotocin plus vehicle (distilled water) (STZ) group. B1, B2, and B3, (−)-epicatechin-3-O-β-D-allopyranoside (BB) (B1, B2, and B3, 10, 20, and 40 mg/kg body weight, respectively); metformin (Metf; 300 mg/kg body weight); fenofibrate (Feno, 250 mg/kg body weight).