Table 1. Effects of Methotrexate (MTX) and Sitagliptin (Sita) on blood glucose level and biochemical parameters of liver function.
| Groups | Glucose (mg/dL) | ALT (IU/L) | AST (IU/L) | ALP (IU/L) | LDH (IU/L) |
|---|---|---|---|---|---|
| Control | 94.2 ± 5.4 | 32.6 ± 3.8 | 53.7 ± 5.0 | 28.1 ± 2.5 | 83.7 ± 6.9 |
| MTX | 109.1 ± 4.9 | 209.3 ± 22.1 *** | 317.6 ± 30.1 *** | 196.7 ± 16.8 *** | 408.2 ± 25.6 *** |
| Sita (10 mg/kg) + MTX | 103.3 ± 6.4 | 138.7 ± 5.4 ***### | 208.5 ± 12.1 ***### | 161.3 ± 5.2 ***# | 342.5 ± 11.7 ***# |
| Sita (20 mg/kg) + MTX | 96.1 ± 4.1 | 97.6 ± 4.9 **### | 159.0 ± 14.4 **### | 61.3 ± 3.8 ### | 194.5 ± 9.2 ***### |
| Sita (20 mg/kg) | 90.9 ± 6.8 | 36.5 ± 2.7 | 50.3 ± 3.1 | 25.1 ± 1.8 | 91.9 ± 6.1 |
n = 10.
**P < 0.01,
***P < 0.001 vs. the control.
#P < 0.05,
###P < 0.001 vs. the MTX group (ANOVA followed by Tukey-Kramer multiple comparison).