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. 2017 Mar 23;12(3):e0174295. doi: 10.1371/journal.pone.0174295

Table 2. Effects of Methotrexate (MTX) and Sitagliptin (Sita) on oxidative stress markers in the liver.

Groups	Parameters
Groups	TAC (mmol/g tissue)	MDA (nmol/g tissue)	SOD (Units/g tissue)	GSH (μmol/g tissue)
Control	0.8 ± 0.04	25.2 ± 1.7	16.3 ± 1.4	10.8 ± 1.2
MTX	0.4 ± 0.03 ^***	49.1 ± 3.9 ^***	6.0 ± 0.1 ^***	5.3 ± 0.1 ^***
Sita (10 mg/kg) + MTX	0.5 ± 0.03 ^***	46.1 ± 3.9 ^***	7.3 ± 1.1 ^***	7.7 ± 0.2 ^*
Sita (20 mg/kg) + MTX	0.6 ± 0.03 ^*^###	33.3 ± 2.8 ^##	12.7 ± 0.9 ^###	9.5 ± 0.8 ^##

n = 10.

* P<0.05,

*** P<0.001 vs. the control.

^##P<0.01,

^### P<0.001 vs. the MTX group (one-way ANOVA followed by Tukey-Kramer multiple comparison)