Table 1. Characteristics of the pooled HEMATURIA cohort.
| Cohort | Origin | N | Mild | Severe | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | Age: mean (SD) | Females: N (%) | With ESRD: N (%) | N (%) | Age: mean (SD) | Females: N (%) | With ESRD: N (%) | |||
| A. Heterozygous for collagen IV mutationsa | Cyprus | 103 | 44 (43%) | 60.3 (±10.3) | 26 (59%) | 0 | 59 (57%) | 62.6 (±12.9) | 26 (44%) | 20 (34%) |
| B. Familial cases of MHb | Cyprus, Greece | 69 | 35 (50%) | 53.7 (±8.7) | 28 (80%) | 0 | 34 (50%) | 55.8 (±12.5) | 13 (38%) | 12 (35%) |
| C. Familial or sporadic cases of MHc | Australia | 34 | 22 (65%) | 53.8 (±9.7) | 15 (41%) | 0 | 12 (35%) | 44.9 (±14.8) | 9 (75%) | 0 |
| D. Patients with IgA nephropathy | Crete (Greece)UK | 318 | 122 (38%) | 40.2 (±11.1) | 51 (42%) | 0 | 196 (62%) | 44.4 (±12.3) | 54 (28%) | 66 (34%) |
MH: Microscopic Hematuria, ESRD: End-Stage Renal Disease
a Of 103 carriers, 78 carried mutation COL4A3-p.G1334E, 19 carried mutation COL4A3-p.G871C and six carried mutation COL4A4-c.3854delG
b “Mild” patients born before 01/1963
c “Mild” patients born before 01/1968. For A, B, C sub-cohorts, age mean difference for Mild and Severe is not significant (p = 0.298).