. 2017 Mar 23;12(3):e0174274. doi: 10.1371/journal.pone.0174274

Table 4. Frequencies and statistics of NEPH3-p.V353M in three general population cohorts including a meta-analysis.

		Genotype counts			Genotype frequency			Allele counts		Allele frequency		Statistics
Cohort	N	VV	VM	MM	VV	VM	MM	V	M	V	M	Dominant model^a	Recessivemodel^a	Odds Ratio (Recessive model)
Controls (without MA)
FHS	5,928	5,508	415	5	0.929	0.070	0.001	11,431	425	0.964	0.036
KORAF4	2,640	2,487	152	1	0.942	0.057	0.001	5,126	154	0.971	0.029
SAPHIR	1,525	1,423	101	1	0.933	0.066	0.001	2,947	103	0.966	0.034
Total (Meta-analysis)	10,093	9,418	668	7	0.933	0.066	0.001	19,504	682	0.966	0.034
Cases (with MA)
FHS	603	561	39	3	0.930	0.065	0.005	1,161	45	0.963	0.037	0.946	1.0x10^-3	5.92 (1.41, 24.85)
KORAF4	397	380	15	2	0.957	0.037	0.006	775	19	0.976	0.024	ND	1.8x10^-2	13.36 (1.21, 147.71)
SAPHIR	165	153	11	1	0.927	0.067	0.006	317	13	0.961	0.039	0.738	0.147	9.29 (0.58, 149.27)
Total (Meta-analysis)	1,165	1,094	65	6	0.939	0.056	0.005	2,253	77	0.967	0.033	ND	1.3x10^-5	7.46 (2.50, 22.23)

MA: Micro-albuminuria, as defined in Methods section; ND: Not done

^a Adjusted p-values for gender and age