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. 2017 Feb 14;50(4):1109–1115. doi: 10.3892/ijo.2017.3876

Figure 1.

Figure 1

Altered expression of miR-21, EMT-related genes, KLF4, Akt and ERK after transfection with miR-21 mimic, miR-21 inhibitor, or control. (A) QBC939 cells treated with miR-21 mimic showed increased expression of miR-21, whereas cells treated with the miR-21 inhibitor showed decreased expression of miR-21 compared to the NC group (P<0.01). (B) Clustered and (C) pathway enrichment of differentially expressed genes induced by miR-21 knockdown. (D and E) Altered levels of KLF4 and ERK by qPCR. The qPCR reactions were performed in triplicate. As loading control, 18S rRNA was used. (**P<0.01, compared with NC group).