Figure 1.
UBE2C and AURKA genes were analyzed by eGWAS. (A) AURKA (yellow) is the hub gene by integrating the experiments, database and literature, and UBE2C (green) shows strong linkage. (B) AURKA, RFC4 and UBE2C were markedly differentially expressed genes from network analyzed. (C) GO analysis demonstrates that the differentially expressed genes are significantly enriched in the cell cycle and collagen and UBE2C is significantly increased during the cell cycle and in the organelle lumen (the Bonferroni threshold, P<1.0×10−5). UBE2C, ubiquitin-conjugating enzyme 2C; Aurora-A (AURKA); eGWAS, genome-wide association study; GO, Gene Ontology.