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. 2017 Feb 17;50(4):1116–1126. doi: 10.3892/ijo.2017.3880

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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UBE2C induces EMT via Wnt/β-catenin and PI3K/Akt signaling pathways. (A) qt-PCR assay for assessing the levels of Twist and E-cadherin in gastric cells after si-UBE2C-treatment. (B) Western blot analysis assay for the expression of EMT-related factors in si-UBE2C-treated cells. (C) si-UBE2C suppresses the Wnt/β-catenin and PI3K/Akt signaling pathways through inhibition of p-AURKA. In particular, si-UBE2C inhibits the phosphorylation of AKT1 and GSK-3β as well as the EMT process. UBE2C, ubiquitin-conjugating enzyme 2C; EMT, epithelial-mesenchymal transition; p-AURKA, phosphorylation AURKA.