Table 4.
Antibiotics used within 3 days of delivery and new drug-class allergies reported within 30 days of peripartum antibiotic exposures in pregnant women with group B streptococcus infection who delivered between 2009 and 2014
| Peripartum antibiotic exposure | History of penicillin allergy (n = 3500)a | No history of penicillin allergy (n = 39,024)a | p value |
|---|---|---|---|
| Penicillin pregnancies | |||
| Number (%) | 130 (3.77) | 32,657 (83.68) | < 0.0001b |
| Total courses | 262 | 71,739 | < 0.0001c |
| New penicillin allergy, no. (%) | NA | 15 (0.04) | — |
| Clindamycin pregnancies | |||
| Number (%) | 2031 (58.03) | 1269 (3.25) | < 0.0001b |
| Total courses | 2232 | 1365 | 0.0365c |
| New clindamycin allergy, no. (%) | 12 (0.34) | 3 (0.01) | < 0.0001 |
| Cefazolin pregnancies | |||
| Number (%) | 1332 (38.06) | 10,626 (27.23) | < 0.0001b |
| Total courses | 2379 | 14,504 | < 0.0001c |
| Other cephalosporin pregnancies | |||
| Number (%) | 27 (0.77) | 274 (0.70) | 0.6395b |
| Total courses | 30 | 356 | 0.7661c |
| New cephalosporin allergy, no. (%) | 10 (0.29) | 19 (0.05) | < 0.0001 |
| Vancomycin pregnancies | |||
| Number (%) | 481 (13.74) | 61 (0.16) | < 0.0001b |
| Total courses | 713 | 93 | 0.6879c |
| New vancomycin allergy, no. (%) | 22 (0.63) | 3 (0.01) | < 0.0001 |
| Gentamicin pregnancies | |||
| Number (%) | 371 (10.60) | 2339 (5.99) | < 0.0001b |
| Total courses | 784 | 5664 | < 0.0001c |
| New gentamicin allergy, no. (%) | 4 (0.11) | 0 (0) | < 0.0001 |
| Azithromycin pregnancies | |||
| Number (%) | 89 (2.54) | 665 (1.70) | 0.0003b |
| Total courses | 128 | 954 | 0.0045c |
| New azithromycin allergy, no. (%) | 1 (0.03) | 2 (0.01) | 0.2272 |
| Other pregnancies (no antibiotic exposure) | |||
| Number (%) | 51 (1.46) | 315 (0.81) | 0.0001b |
| Total courses | 57 | 386 | 0.0095c |
A woman may have multiple deliveries during the study interval, and each delivery is counted as an independent event. All descriptive statistics and statistical tests are at delivery level, not patient level.
p value for testing whether the percentage exposed to specific antibiotic is different for those with penicillin allergy from those without penicillin allergy.
p value for testing whether the mean number of courses exposed to specific antibiotic is different for those with penicillin allergy from those without penicillin allergy (among those exposed).
NA = not applicable.