Table 2. Univariate and multivariate Cox survival analysis in the entire hepatocellular carcinoma cohort.

n = 3,182	Crude Hazard Ratio		Adjusted Hazard Ratio
	HR (95% CI)	P value	HR (95% CI)	P value
Diabetes mellitus (no/yes)	1.17 (1.03–1.33)	0.019	1.09 (0.95–1.25)	0.199
Age (per 10 years increment)	1.05 (1.00–1.10)	0.030	1.14 (1.09–1.20)	<0.001
Male gender (female/male)	1.16 (1.01–1.33)	0.039	1.07 (0.92–1.24)	0.370
Hepatitis B (negative/positive)	0.93 (0.83–1.04)	0.222	-	-
Hepatitis C (negative/positive)	0.84 (0.74–0.95)	0.007	0.97 (0.85–1.12)	0.702
Alcoholism (no/yes)	1.37 (1.19–1.59)	<0.001	1.16 (0.99–1.35)	0.064
Albumin (per 1 g/dl increment)	0.38 (0.35–0.42)	<0.001	0.55 (0.50–0.61)	<0.001
Bilirubin (per 1 mg/dl increment)	1.14 (1.13–1.15)	<0.001	1.07 (1.05–1.09)	<0.001
INR (per 1.0 increment)	4.80 (3.92–5.87)	<0.001	1.59 (1.18–2.13)	0.002
Sodium (per 1 mEq/l increment)	0.90 (0.89–0.92)	<0.001	0.98 (0.97–1.00)	0.029
AFP (per 10,000 ng/ml increment)	1.01 (1.01–1.01)	<0.001	1.01 (1.01–1.01)	<0.001
eGFR (per 10 mL/min/1.73 m2 increment)	0.96 (0.94–0.98)	<0.001	0.98 (0.96–0.99)	0.010
Variceal bleeding (no/yes)	2.17 (1.66–2.83)	<0.001	1.13 (0.85–1.49)	0.404
Total tumor volume (per 1,000 ml increment)	1.54 (1.48–1.61)	<0.001	1.22 (1.15–1.30)	<0.001
Vascular invasion (no/yes)	5.01 (4.42–5.68)	<0.001	3.20 (2.77–3.70)	<0.001
Ascites (no/yes)	3.52 (3.11–3.99)	<0.001	1.72 (1.48–1.99)	<0.001
Platelet count (per 10,000 mm3 increment)	1.03 (1.02–1.03)	<0.001	1.01 (1.01–1.02)	<0.001

Factors with P value < 0.1 in the univariate analysis were introduced into the Cox multivariate survival analysis.

The forepart of the parentheses was set as the reference group in univariate and multivariate analysis.

AFP, alpha-fetoprotein; CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio; INR, international normalized ratio