Table 5. Univariate and multivariate Cox survival analysis in patients with BCLC stage C and stage D hepatocellular carcinoma.

n = 1,678	Crude Hazard Ratio		Adjusted Hazard Ratio
	HR (95% CI)	P value	HR (95% CI)	P value
Diabetes mellitus (no/yes)	0.88 (0.75–1.04)	0.136	-	-
Age (per 10 years increment)	0.99 (0.94–1.04)	0.589	-	-
Male gender (female/male)	1.19 (0.99–1.42)	0.059	1.09 (0.90–1.30)	0.387
Hepatitis B (negative/positive)	1.04 (0.90–1.20)	0.582	-	-
Hepatitis C (negative/positive)	0.81 (0.68–0.96)	0.013	1.00 (0.83–1.19)	0.954
Alcoholism (no/yes)	1.08 (0.91–1.28)	0.371	-	-
Albumin (per 1 g/dl decrement)	2.08 (1.85–2.27)	<0.001	1.67 (1.47–1.89)	<0.001
Bilirubin (per 1 mg/dl increment)	1.11 (1.09–1.12)	<0.001	1.06 (1.04–1.08)	<0.001
INR (per 1.0 increment)	3.13 (2.46–3.97)	<0.001	1.22 (0.86–1.72)	0.260
Sodium (per 1 mEq/l decrement)	1.09 (1.06–1.10)	<0.001	1.02 (1.01–1.04)	0.006
AFP (per 10,000 ng/ml increment)	1.01 (1.01–1.01)	<0.001	1.01 (1.00–1.01)	<0.001
eGFR (per 10 mL/min/1.73 m2 decrement)	1.03 (1.01–1.05)	0.010	1.03 (1.01–1.05)	0.003
Variceal bleeding (no/yes)	1.38 (1.04–1.83)	0.024	1.00 (0.74–1.34)	0.983
Total tumor volume (per 1,000 ml increment)	1.33 (1.26–1.40)	<0.001	1.12 (1.04–1.20)	0.002
Vascular invasion (no/yes)	2.59 (2.24–3.00)	<0.001	2.34 (1.99–2.74)	<0.001
Ascites (no/yes)	2.26 (1.95–2.61)	<0.001	1.63 (1.39–1.92)	<0.001
Platelet count (per 10,000 mm3 increment)	1.02 (1.02–1.03)	<0.001	1.01 (1.01–1.02)	<0.001

Factors with P value < 0.1 in the univariate analysis were introduced into the Cox multivariate survival analysis.

The forepart of the parentheses was set as the reference group in univariate and multivariate analysis.

AFP, alpha-fetoprotein; CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio; INR, international normalized ratio