Table 1. Duration of nerve blockades from QX-314 in combination with bupivacaine.
| Combinations | Abbreviation | n | Sensory duration, h | Motor duration, h | |
|---|---|---|---|---|---|
| QX-314, mmol/L (w/v %) | Bupi, mmol/L (w/v %) | ||||
| 5 (0.2) | 5 (0.2) | Q5B5 | 6 | 4.2 ± 1.9 | 4.0 ± 1.1 |
| 10 (0.3) | 10 (0.3) | Q10B10 | 10 | 6.0 ± 2.2 | 5.2 ± 1.9 |
| 15 (0.5) | 3 (0.1) | Q15B3 | 6 | 5.8 ± 3.4 | 5.1 ± 2.2 |
| 15 (0.5) | 10 (0.3) | Q15B10 | 10 | 5.8 ± 2.1 | 5.6 ± 1.8 |
| 15 (0.5) | 15 (0.5) | Q15B15 | 8 | 5.2 ± 3.0 | 3.8 ± 1.3 |
| 20 (0.7) | 5 (0.2) | Q20B5 | 10 | 5.8 ± 1.6 | 5.8 ± 1.6 |
| 20 (0.7) | 10 (0.3) | Q20B10 | 8 | 7.3 ± 2.3 | 6.3 ± 3.3 |
| 20 (0.7) | 15 (0.5) | Q20Q15 | 8 | 6.8 ± 3.0 | 6.1 ± 3.1 |
| 25 (0.9) | 5 (0.2) | Q25Q5 | 10 | 8.6 ± 6.1 | 6.2 ± 2.5 |
| 25 (0.9) | 10 (0.3) | Q25B10 | 8 | 9.0 ± 3.0 | 5.7 ± 2.3 |
| 25 (0.9) | 15 (0.5) | Q25B15 | 6 | 10.1 ± 0.8* | 10.1 ± 0.8* |
| 35 (1.2) | 1 (0.03) | Q35B1 | 6 | 15.2 ± 6.8** | 14.5 ± 7.3** |
| 45 (1.5) | 10 (0.3) | Q45B10 | 6 | 23.8 ± 0*** | 23.8 ± 0** |
| 15 mmol/L (0.5%) Bupi | B15 | 8 | 3.6 ± 1.3 | 4.0 ± 0.8 | |
| Saline | Saline | 6 | 0 | 0 | |
Bupi: bupivacaine.
* P < 0.05 vs. 0.5% Bupivacaine;
** P < 0.01 vs. 0.5% Bupivacaine;
*** P < 0.001 vs. 0.5% Bupivacaine.