Table 2.

Genome-Wide Significant Associations for Emphysema Distribution Phenotypes

					Metaanalysis		COPDGene NHW (n = 6,215)		COPDGene AA (n = 2,955)		ECLIPSE (n = 1,538)		GenKOLS (n = 824)
SNP	Locus	Nearest Gene	Effect Allele	Effect Allele Frequency	Effect Size	P Value	Effect Size (SE)	P Value	Effect Size (SE)	P Value	Effect Size (SE)	P Value	Effect Size (SE)	P Value
diff950
rs138544659	15q25	CHRNA3/5	T	0.70	−0.12	9.87 × 10−15	−0.12 (0.02)	1.22 × 10−9	−0.12 (0.04)	0.002	−0.12 (0.04)	0.003	−0.12 (0.05)	0.03
rs13141641	4q31	HHIP	T	0.63	0.09	1.76 × 10−11	0.10 (0.02)	6.51 × 10−9	0.03 (0.04)	0.45	0.13 (0.03)	0.0002	0.05 (0.05)	0.24
ratio950
rs13141641	4q31	HHIP	T	0.62	0.12	6.34 × 10−18	0.15 (0.02)	4.92 × 10−17	0.04 (0.04)	0.34	0.11 (0.03)	0.002	0.05 (0.04)	0.24
rs12914385	15q25	CHRNA3/5	T	0.38	0.11	1.72 × 10−17	0.13 (0.02)	4.36 × 10−14	0.07 (0.03)	0.03	0.08 (0.04)	0.02	0.13 (0.04)	0.003
rs2645694	4q13	SOWAHB	T	0.30	0.08	2.42 × 10−8	0.08 (0.02)	1.93 × 10−5	0.08 (0.03)	0.003	0.07 (0.04)	0.1	0.07 (0.05)	0.17
rs75755010	8q24	TRAPPC9	A	0.08	−0.15	3.43 × 10−8	−0.15 (0.04)	0.001	−0.19 (0.04)	4.98 × 10−6	−0.01 (0.09)	0.9	−0.10 (0.10)	0.31
rs35374984	10p12	KIAA1462	A	0.29	0.10	3.83 × 10−8	0.09 (0.03)	0.001	0.10 (0.03)	0.0004	0.12 (0.06)	0.06	0.18 (0.08)	0.03

Definition of abbreviations: AA = African American; COPDGene = Genetic Epidemiology of COPD; diff950 = inverse normally transformed upper-third/lower-third percent emphysema difference; ECLIPSE = Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints; GenKOLS = Genetics of Chronic Obstructive Lung Disease; NHW = non-Hispanic white; ratio950 = inverse normally transformed upper-third/lower-third percent emphysema ratio; SNP = single-nucleotide polymorphism.

Results of the individual studies and metaanalysis are shown.