Table 3.

Analyses in COPD Cases Only and Only in Subjects with More Than 5% Total Emphysema

				diff950 Metaanalysis						ratio950 Metaanalysis
				All Subjects (n = 11,532)		Cases (n = 5,079)		Subjects with Total Emphysema ≥5% (n = 4,182)		All Subjects (n = 11,532)		Cases (n = 5,079)		Subjects with Total Emphysema ≥5% (n = 4,182)
SNP	Locus	Nearest Gene	Effect Allele	Effect Size	P Value	Effect Size	P Value	Effect Size	P Value	Effect Size	P Value	Effect Size	P Value	Effect Size	P Value
rs138544659	15q25	CHRNA3/5	T	−0.12	9.87 × 10−15	−0.16	1.19 × 10−9	−0.18	1.21 × 10−7	−0.13	8.04 × 10−16	−0.16	1.9 × 10−12	−0.12	2.72 × 10−8
rs13141641	4q31	HHIP	T	0.09	1.76 × 10−11	0.14	2.61 × 10−9	0.15	1.09 × 10−7	0.12	6.34 × 10−18	0.15	1.59 × 10−12	0.11	3.01 × 10−8
rs12914385	15q25	CHRNA3/5	T	0.10	1.13 × 10−12	0.13	6.5 × 10−8	0.12	4 × 10−5	0.11	1.72 × 10−17	0.14	8.86 × 10−12	0.08	2.29 × 10−5
rs2645694	4q13	SOWAHB	T	0.05	0.0002	0.06	0.02	0.06	0.06	0.08	2.42 × 10−8	0.02	0.001	0.04	0.06
rs75755010	8q24	TRAPPC9	A	−0.08	0.002	−0.08	0.16	−0.08	0.26	−0.15	3.43 × 10−8	−0.14	0.001	−0.08	0.08
rs35374984	10p12	KIAA1462	A	0.08	7.11 × 10−6	0.09	0.01	0.12	0.01	0.10	3.83 × 10−8	0.10	0.001	0.08	0.004

Definition of abbreviations: COPD = chronic obstructive pulmonary disease; diff950 = inverse normally transformed difference between upper-third and lower-third emphysema; ratio950 = inverse normally transformed ratio between upper-third and lower-third emphysema; SNP = single-nucleotide polymorphism.

The SNPs included are the ones that reached genome-wide significance in all subjects. The numbers reported are the effect sizes and P values of the metaanalyses performed in the corresponding subgroup.