Table 5.
Association between rs4809324 and risk of COPD in multiple inheritance models (adjusted by gender, age, and smoking status)
| Model | Genotypes | Case | Control | Without adjustment
|
With adjustment
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | AIC | BIC | OR (95% CI) | P-value | AIC | BIC | ||||
| Codominant | T/T | 171 (62.4%) | 182 (63.2%) | 1 | 0.022* | 784.1 | 797.1 | 1 | 0.022* | 632.7 | 658.7 |
| T/C | 97 (35.4%) | 88 (30.6%) | 1.18 (0.83–1.68) | 1.25 (0.83–1.88) | |||||||
| C/C | 6 (2.2%) | 18 (6.2%) | 0.33 (0.13–0.86) | 0.28 (0.10–0.85) | |||||||
| Dominant | T/T | 171 (62.4%) | 182 (63.2%) | 1 | 0.87 | 789.7 | 798.4 | 1 | 0.7 | 638.2 | 659.9 |
| T/C-C/C | 103 (37.6%) | 106 (36.8%) | 1.03 (0.73–1.45) | 1.08 (0.73–1.60) | |||||||
| Recessive | T/T-T/C | 268 (97.8%) | 270 (93.8%) | 1 | 0.009* | 782.9 | 791.6 | 1 | 0.009* | 631.9 | 653.6 |
| C/C | 6 (2.2%) | 18 (6.2%) | 0.32 (0.12–0.80) | 0.26 (0.09–0.78) | |||||||
| Overdominant | T/T-C/C | 177 (64.6%) | 200 (69.4%) | 1 | 0.2 | 788.1 | 796.8 | 1 | 0.15 | 636.3 | 658 |
| T/C | 97 (35.4%) | 88 (30.6%) | 1.26 (0.88–1.78) | 1.34 (0.90–2.01) | |||||||
| Log-additive | – | – | – | 0.89 (0.67–1.19) | 0.44 | 789.1 | 797.8 | 0.91 (0.65–1.28) | 0.6 | 638.1 | 659.7 |
Note:
*
P-value ≤0.05 indicates statistical significance.
Abbreviations: OR, odds ratio; CI, confidence interval; COPD, chronic obstructive pulmonary disease; AIC, Akaike’s Information criterion; BIC, Bayesian Information criterion.