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. 2017 Mar 17;12:2129–2142. doi: 10.2147/IJN.S126016

Figure 4.

Figure 4

Reduction of particle phagocytosis via hCTL membrane coating.

Notes: (A) Internalization of uncoated and hCTL membrane-coated PLGA nanoparticles in phagocytic cells. DiO-loaded PLGA nanoparticles were incubated with PMA-differentiated THP-1 cells. Cells with internalized nanoparticles were quantified using flow cytometry (N=3; **P<0.01). (B) Representative flow cytometry histograms of phagocytic THP-1 cells with internalized PLGA nanoparticles.

Abbreviations: hCTL, human cytotoxic T lymphocyte; PLGA, poly-lactic-co-glycolic acid; FITC, fluorescein isothiocyanate.