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. 2017 Mar 17;12:2129–2142. doi: 10.2147/IJN.S126016

Figure 7.

Figure 7

Antitumor efficacy of PTX-loaded TPNPs.

Notes: (A) Schematic of the experimental procedure for combined LDI and targeted chemotherapy. (B) and (C) Mice were treated with NS, free PTX, PTX-loaded TPNPs, LDI, or PTX-loaded TPNPs + LDI (n=5). (D) H&E-stained sections of major organs collected from different treatment groups of mice on day 16. Scale bar =100 μm. *P<0.05, ***P<0.005, ****P<0.001.

Abbreviations: CR, complete remission; LDI, low-dose irradiation; NS, normal saline; PLGA, poly-lactic-co-glycolic acid; PTX, paclitaxel; T-PLGA–PTX, PTX-loaded PLGA nanoparticles with human cytotoxic T-lymphocyte membrane encapsulation; TPNPs, T-lymphocyte membrane-coated PLGA nanoparticles; H&E, hematoxylin–eosin.