Table 7.
Change of corneal and conjunctival fluorescein staining scores in prospective randomized study
| Examination point
|
Amount of change | Comparison within-group one-sample t-test (P-value) | ||
|---|---|---|---|---|
| Before treatment (4 weeks after surgery) | After treatment (8 weeks after surgery) | |||
| Total patients | ||||
| DQS | ||||
| Mean ± SD | 2.1±0.9 | 1.6±1.2 | −0.6±1.2 | <0.001** |
| Median | 2.0 | 1.0 | −1.0 | |
| Number of patients | 75 | 75 | 75 | |
| AT | ||||
| Mean ± SD | 2.4±1.1 | 1.8±1.3 | −0.6±1.2 | <0.001** |
| Median | 2.0 | 2.0 | 0.0 | |
| Number of patients | 79 | 78 | 78 | |
| Comparison between groups two-sample t-test (P-value) | 0.169 | 0.322 | 0.826 | |
| The definite dry eye patient before surgery | ||||
| DQS | ||||
| Mean ± SD | 2.9±0.9 | 2.3±1.3 | −0.6±1.3 | <0.077 |
| Median | 3.0 | 2.0 | −0.5 | |
| Number of patients | 20 | 20 | 20 | |
| AT | ||||
| Mean ± SD | 2.8±1.3 | 2.5±1.2 | −0.4±1.2 | <0.153 |
| Median | 2.0 | 2.5 | 0.0 | |
| Number of patients | 25 | 24 | 24 | |
| Comparison between groups two-sample t-test (P-value) | 0.887 | 0.674 | 0.653 | |
Notes:
**
P<0.001, corneal and conjunctival fluorescein staining scores were evaluated in three areas (the temporal bulbar conjunctiva, nasal bulbar conjunctiva, and cornea), scored on a 0- to 3-point scale (0: no damage to 3: damage in the entire area) and then totaled (maximum =9 points).
Abbreviations: AT, artificial tears; DQS, diquafosol ophthalmic solution; SD, standard deviation.