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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Neurorehabil Neural Repair. 2017 Jan 20;31(4):387–396. doi: 10.1177/1545968316688800

Figure 1. Timeline.

Figure 1

Timeline shows experimental design for bolus infusion of 4-AP along with the physiology and blood plasma collection set-up. Femoral vein was catheterized for plasma collection and an intraperitoneal catheter was also placed for continuous infusion of anesthesia. Bipolar cortical and spinal electrodes were placed over the forelimb area and the cervical region of spinal cord respectively. Also, bicep brachii muscle was implanted with steel EMG electrode. Animals in injury group were pyramidotomized one week prior to physiology experiments. Following i.p. injection of the drug, the cortical and spinal physiology data were collected at different time points (black arrows) as shown and 300 uL of blood plasma was also collected at different time points (grey arrows).