Figure 2.
miR-155 deficiency was associated with improved survival despite increased peripheral parasitemia in P. berghei ANKA (PbA)-induced ECM. (A) Survival was improved in mice deficient in miR-155. Survival of albino C57BL/6 miR-155-/- versus wild-type miR-155+/+ littermate controls infected with 1 × 106 parasitized erythrocytes was compared, and miR-155-/- animals displayed significantly better survival (****P < 0.0001; log-rank test; n = 26/group). (B) Peripheral parasitemia was greater in mice deficient in miR-155. Mean peripheral parasitemia in miR-155-/- versus wild-type mice infected with 1 × 106 parasitized erythrocytes was compared, and peripheral parasitemia was significantly higher in miR-155-/- than wild-type mice (****P < 0.0001; linear mixed-effects model; n = 26/group). Experiment was repeated for confirmation of findings. Error bars represent standard deviation.