Figure 4.

miR-155 deficiency is associated with decreased endothelial activation during P. berghei ANKA (PbA)-induced ECM. Median plasma protein levels of endothelial activation markers in albino C57BL/6 miR-155^-/- and wild-type miR-155^+/+ littermate controls on d 6 post-PbA infection (1 × 10⁶ parasitized erythrocytes), measured by ELISA. Ang-1 was significantly higher, while Ang-2, Ang-2:Ang-1 ratio and sE-selectin were significantly lower in miR-155^-/- than wild-type PbA-infected mice (*P < 0.05, **P < 0.01, ****P < 0.0001; Welch’s t test or Mann-Whitney test, where applicable; n = 23–45/group). Experiment was repeated for confirmation of findings. Error bars represent interquartile range. Abbreviations: Ang-1, angiopoietin-1; Ang-2, angiopoietin-2; sE-selectin, soluble E-selectin.